Job Description

Job Description

Job Description

Salary: $127,472-$191,555

General Summary

We are seeking a highly motivated and collaborative leader with a strong creative mindset and a deep understanding of drug discovery processes in the ADC field. The ideal candidate will be a subject matter expert in antibody-drug conjugates, including next-generation ADC platform technologies, with a proven track record of successfully identifying clinical development candidates. Additionally, they should demonstrate an ability to adapt to new therapeutic areas as Orum expands its pipeline.

Duties and Responsibilities

• Drive technological advancements and support the team's efforts in developing and implementing bioconjugation techniques for the creation of targeted conjugate biotherapeutics, including antibody-drug conjugates.
• Oversee and support both internal and external research and CMC efforts in bioconjugation initiatives. Troubleshoot issues as they arise and ensure the timely delivery of high-quality conjugates.
• Collaborate closely with the medicinal chemistry team to advance antibody-drug conjugates from hit identification to lead optimization and candidate selection, focusing on improving conjugation processes and analytical characterization methods.
• Engage and collaborate with leaders and teams across key therapeutic areas to support pipeline delivery and develop modern technologies.
• Partner with business development teams to explore and expand external collaborations.
• Cultivate a culture of transparency, innovation, and creativity to foster new opportunities for the company and the development of intellectual property.
• Contribute to the chemistry strategy in alignment with project objectives.
• Keep up to date knowledge on technological advancements in the targeted delivery space.
• Present scientific updates and communicate research findings effectively during internal and external project team meetings, influencing strategic R&D decisions.
• Mentor junior team members to support their development and growth.

Skills, Abilities & Competencies

• Extensive experience in the biopharmaceutical industry.
• Track record of accomplishment in bioconjugation and/ or synthetic chemistry, as indicated by publications in peer reviewed journals.
• Extensive experience in bioconjugation reactions, techniques and approaches and experience with protein bioanalytical techniques (e.g. HPLC, LC-MS, UV-spectrophotometry, etc.)
• Extensive knowledge of critically relevant areas such as analytical characterization, formulation, and the general CMC scope for ADCs.
• Experience with design and synthesis of conditional release linkers and/or prodrugs.
• Familiarity with structure-activity and structure-property relationships for small molecules, PPI inducers, and/ or antibody drug conjugates.
• Willingness to explore and apply new bioconjugation techniques and become fully integrated into Orum’s discovery efforts for next-gen drug conjugates.
• Strong communication and time-management skills, the ability to handle multiple projects simultaneously, and the ability to effectively collaborate with a global multidisciplinary team.
• Collaborative team player with excellent interpersonal and communication skills.
• Strong work ethic and ability to work independently with minimal supervision.

Education- Ph.D. or equivalent degree in organic/medicinal chemistry or a related field with minimum 5 years' bioconjugation experience, MS degree with 8 years', or BS degree with 11 years' experience.

*U.S. citizens and those authorized to work in the U.S. (green card) are encouraged to apply. We are unable to sponsor at this time.

*Candidate must be able to pass a background investigation.

*Unable to work with 3rd party candidates or agencies.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily within the context of the representative work environment and physical demands described above. Likewise, qualifications listed are representative of the knowledge, skills, and abilities required to perform the position’s essential functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Orum Therapeutics is an Equal Opportunity Employer (EOE).

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